leucine enkephalin acetate hydrate
[LEU5]-ENKEPHALIN
CAS: 58822-25-6
Molecular Formula: C28H37N5O7
leucine enkephalin acetate hydrate - Names and Identifiers
leucine enkephalin acetate hydrate - Physico-chemical Properties
| Molecular Formula | C28H37N5O7 |
| Molar Mass | 555.62 |
| Density | 1.274±0.06 g/cm3(Predicted) |
| Melting Point | 130-133 °C |
| Boling Point | 998.8±65.0 °C(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Biological activity [Leu5]-Enkephalin is a pentapeptide with morphine properties. As an opioid receptor (opioid receptors) agonist. |
leucine enkephalin acetate hydrate - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
leucine enkephalin acetate hydrate - Reference
| Reference Show more | 1. [IF=4.36] Xiaoli Wang et al."Network pharmacology combined with metabolomics to study the mechanism of Shenyan Kangfu Tablets in the treatment of diabetic nephropathy."J Ethnopharmacol. 2021 Apr;270:113817 |
leucine enkephalin acetate hydrate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.8 ml | 8.999 ml | 17.998 ml |
| 5 mM | 0.36 ml | 1.8 ml | 3.6 ml |
| 10 mM | 0.18 ml | 0.9 ml | 1.8 ml |
| 5 mM | 0.036 ml | 0.18 ml | 0.36 ml |
Last Update：2024-01-02 23:10:35
leucine enkephalin acetate hydrate - Uses and synthesis methods
biological activity
[Leu5]-Enkephalin is a pentapeptide with morphine properties. As an opioid receptor (opioid receptors) agonist.
target
Human Endogenous Metabolite
in vitro study
Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. K I =18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas. Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.
Last Update：2024-04-10 22:29:15
leucine enkephalin acetate hydrate - Nature
| melting point | 130-133 °C |
| specific rotation | 32.3°(c=9,メタノール) |
| boiling point | 998.8±65.0 °C(Predicted) |
| density | 1.274±0.06 g/cm3(Predicted) |
| storage conditions | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| acidity coefficient (pKa) | 3.40±0.10(Predicted) |
| water solubility | Soluble in water (1 mg/ml ). |
Last Update：2024-04-09 21:31:46
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View History
leucine enkephalin acetate hydrate
Isovaleric acid isoamyl ester
2-氯-6-羟基苯甲酸乙酯
LOTSORB UV 988
2022983-68-0
8,13-BIS(2-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
Einecs 258-597-0
(R)-3-1(-DIMETHYLAMINO)ETHYLPHENOL
Isovaleric acid, cinnamyl ester (6CI,7CI,8CI)
Irinotecan HCL 3H2O
Isovaleric acid isoamyl ester
2-氯-6-羟基苯甲酸乙酯
LOTSORB UV 988
2022983-68-0
8,13-BIS(2-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
Einecs 258-597-0
(R)-3-1(-DIMETHYLAMINO)ETHYLPHENOL
Isovaleric acid, cinnamyl ester (6CI,7CI,8CI)
Irinotecan HCL 3H2O